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Seizures are a side effect with Contrave and mustn't be taken in people who have seizure disorders. The drug can also raise blood pressure levels and heart rate, and mustn't be used in those with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise blood pressure and heartbeat and must stop used in patients with uncontrolled high blood pressure, as well as by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting your brain) disease. Patients with a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients to the increased probability of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stopping smoking.

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