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The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in older adults with a body mass index (BMI) of more than 27, provided that they also are afflicted by weight-related health issues such as Tupe2 diabestes, high cholesterol and/or hypertension (high blood pressure).Contrave is often a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder and as an aid to stop smoking treatment.'Obesity may be a major public health concern,' said Jean-Marc Guettier, M.D., director of the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle that features a reduced-calorie eating and working out, Contrave provides another treatment selection for chronic weight loss for people who are obese or are overweight and have at least one weight-related health.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that contained a reduced- calorie diet and regular physical exercise. Results from a clinical trial that enrolled patients without diabetes demonstrated that patients had a normal weight loss of four.1% as opposed to participants who have been given placebos) within a 12- month period, while a separate study involving patients with diabetes type 2 symptoms had a typical weight loss of 2% over treatment with placebo at one full year.

Using two separate drugs to shed pounds can be very effective you will find combinations while watching FDA now awaiting approval. When dealing with fat loss and the people who go through it you need to err to the side of caution and allow FDA do its job and demand some investigation be done so the public knows the side effects and perils associated with the medications before we drive them. Keep in mind that drug companies will be in business to earn money and that they would say anything to keep people on their medications.

Researchers found out that participants investing in this drug to get a year, dropped excess weight within a month and have kept the weight off through the 56 weeks with the study. Contrave is often a combination of the drugs naltrexone and bupropion, which usually reflect a brand new trend of weight-loss drugs that are made up of many active ingredient, that might make them more efficient and safer.

Combo-pilling may be the newest fad or better yet the newest in the future under scrutiny and for that reason it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular will be the fact that since right now there are no long term prescription weightloss pills that have been approved by the FDA besides orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be approved by the FDA.

Seizures can be a side effect with Contrave and shouldn't be taken in people who have seizure disorders. The drug can also raise blood pressure levels and heart rate, and mustn't be used in people with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise blood pressure level and heartbeat and must not used in patients with uncontrolled high blood pressure level, as well as by a person with heart-related and cerebrovascular (blood vessel dysfunction impacting mental performance) disease. Patients with a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes with a boxed warning to alert medical researchers and patients towards the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for quitting smoking.

"There were no signs of depression or suicidal thoughts in trial participants," said Fujioka.