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Evidence is increasing that most addiction without exception is related to problems with the brain's reward center, especially the mesolimbic system. This section of the problem regulates reward responses in acquiring food and sex, plus in nurturing infants and children. One of the most important neurotransmitters involved in reward responses, both after they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the quantity of dopamine released in in reaction to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to shed pounds can be very effective you'll find combinations before the FDA now awaiting approval. When dealing with weight reduction and the people that go through it one should err along the side of caution and let the FDA do its job and demand some study be done so the public is aware of the side effects and risks of the medications before we take them. Keep in mind that drug companies will be in business to make money and that they would say everything to keep people on his or her medications.

Researchers found that participants using this drug for the year, lost excess weight within one month and have kept the extra weight off throughout the 56 weeks in the study. Contrave is often a combination in the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs which are made up of multiple active ingredient, which may make them more efficient and safer.

Combo-pilling will be the newest fad or in addition to this the newest into the future under scrutiny and for that reason it is just more publicly known lately, comb-pilling for weight reduction has been around since the eighties. The biggest reason that utilizing a combination of pills is becoming popular will be the fact that as of right now there are no long term prescription diet pills that have been licensed by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be licensed by the FDA.

Seizures can be a side effect with Contrave and shouldn't be taken in people with seizure disorders. The drug could also raise blood pressure level and pulse rate, and must not be used in people who have a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy while using drug.

The FDA also warned that Contrave can raise blood pressure level and heartrate and must not be used in patients with uncontrolled high blood pressure, along with by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting your brain) disease. Patients with a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes which has a boxed warning to alert physicians and patients on the increased risk of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stopping smoking.

New UCLA study on smokers with mental, drug, and alcohol problems


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