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The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment choice for chronic weight loss in addition to a reduced-calorie diet and physical exercise.

Using two separate drugs to shed weight can be very effective you will find combinations in front of the FDA now awaiting approval. When dealing with weight-loss and the people who go through it you need to err along the side of caution and let the FDA do its job and demand some study be done so your public is aware of the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies will be in business to generate income and that they would say almost anything to keep people on their medications.

Researchers found that participants taking this drug for the year, dropped a few pounds within four weeks and have kept the load off through the 56 weeks in the study. Contrave is really a combination of the drugs naltrexone and bupropion, which appears to reflect a fresh trend of weight-loss drugs which might be made up of several active ingredient, which can make them more efficient and safer.

Combo-pilling will be the newest fad or also the newest to come under scrutiny and therefore it is just more publicly known although in the past, comb-pilling to lose weight has been around since the eighties. The biggest reason that utilizing a combination of pills is starting to become popular could be the fact that at the time of right now there are not any long term prescription slimming capsules that have been approved by the FDA apart from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations are already rejected or have yet to be authorized by the FDA.

Seizures can be a side effect with Contrave and must not be taken in those with seizure disorders. The drug can also raise blood pressure level and heart rate, and mustn't be used in those with a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise hypertension and heartrate and must not used in patients with uncontrolled high blood pressure, as well as by you aren't heart-related and cerebrovascular (circulatory dysfunction impacting your brain) disease. Patients having a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes which has a boxed warning to alert medical professionals and patients on the increased risk of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation.

From a psychiatric standpoint, evidence implies that the ordinary neural mechanism for goal-directed behavior continues to be hijacked through the addiction, and malfunctions in such a way that its ordinary functions are exaggerated and fixated on its object. An object produces a stimulus and the person engages in a "goal-directed behavioral response" that creates a "natural high"(Bostwick & Bucci, 2008).


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