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The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help manage chronic obesity in adults with a body mass index (BMI) in excess of 27, provided that they also experience weight-related health concerns such as Tupe2 diabestes, high-cholesterol and/or hypertension (high blood pressure).Contrave is really a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder and as an aid to quitting smoking treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director from the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination which has a healthy lifestyle that includes a reduced-calorie dieting and exercise, Contrave provides another treatment selection for chronic weight loss for people who are obese or are overweight and have at least one weight-related health issue.'The drug's effectiveness was evaluated in multiple many studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that was comprised of a reduced- calorie diet and regular physical activity. Results from a clinical study that enrolled patients without diabetes demonstrated that patients had a typical weight loss of 4.1% instead of participants who were given placebos) after a 12- month period, while an outside study involving patients with type 2 diabetes had a typical weight loss of 2% over treatment with placebo at one full year.

Using two separate drugs to shed weight can be very effective you will find combinations while watching FDA now awaiting approval. When dealing with weight loss and the individuals who go through it you should err to the side of caution and permit the FDA do its job and demand some research be done so that the public is aware of the side effects and dangers of the medications before we bring them. Keep in mind that drug companies come in business to generate income and that they would say everything to keep people on the medications.

Researchers found out that participants using this drug for the year, dropped excess weight within four weeks and have kept the extra weight off throughout the 56 weeks in the study. Contrave can be a combination from the drugs naltrexone and bupropion, which usually reflect a brand new trend of weight-loss drugs that are made up of multiple active ingredient, which might make them more potent and safer.

Combo-pilling is the newest fad or better yet the newest to come under scrutiny and so it is just more publicly known lately, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills is now popular could be the fact that by right now there aren't any long term prescription weight loss supplements that have been licensed by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications however some of the combinations happen to be rejected or have yet to be approved by the FDA.

Seizures really are a side effect with Contrave and really should not be taken in people who have seizure disorders. The drug could also raise blood pressure level and heartbeat, and really should not be used in people with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise blood pressure and heartbeat and must not used in patients with uncontrolled high blood pressure level, along with by you are not heart-related and cerebrovascular (circulation dysfunction impacting the brain) disease. Patients which has a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients to the increased chance of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation.

Approving a drug with this many potentially lethal unwanted side effects is inconsistent while using mission statement of the FDA. The power from the drug manufacturing lobby is blatantly evident inside approval of many drugs requiring 'post-marketing' studies that are clearly significant to overall drug safety inside the US.